Murine segmental duplications are hot spots for chromosome and gene evolution
نویسندگان
چکیده
منابع مشابه
Segmental duplications flank the multiple sclerosis locus on chromosome 17q.
Large chromosomal rearrangements, duplications, and inversions are relatively common in mammalian genomes. Here we report interesting features of DNA strands flanking a Multiple Sclerosis (MS) susceptibility locus on Chromosome 17q24. During the positional cloning process of this 3-Mb locus, several markers showed a radiation hybrid clone retention rate above the average (1.8-fold), suggestive ...
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متن کاملSignals of Historical Interlocus Gene Conversion in Human Segmental Duplications
Standard methods of DNA sequence analysis assume that sequences evolve independently, yet this assumption may not be appropriate for segmental duplications that exchange variants via interlocus gene conversion (IGC). Here, we use high quality multiple sequence alignments from well-annotated segmental duplications to systematically identify IGC signals in the human reference genome. Our analysis...
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ژورنال
عنوان ژورنال: Genomics
سال: 2005
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2005.08.008